Evaluation des biomarqueurs du risque cardio-vasculaire chez les sujets en surcharge pondérale
Main Article Content
Abstract
Objective
-Screening for cardiovascular risk is crucial, particularly in overweight patients. The aim of this study was to measure the correlation between levels of conventional cardiac enzymatic (CPK) markers Creatine Phospho Kinase, LDH Lac- tate dehydrogenase, ASAT Aspartate Amino Transferase and ALAT Alanine Amino Transferase) and body mass index, and to study their association with the reference marker, ultra-sensitive CRP and Liporprotein a in a series of cases.
Materials & Methods
-Sixty-two subjects were included in a descriptive cross-sec- tional study, divided into two groups according to body mass index.
The first group included volunteers of the same sex and age group (BMI ? 25 kg/m²) and the second group normo-weight volunteers (BMI?18.5 kg/m²). An analysis of CPK, LDH, ASAT, ALAT and Liporprotein a ) was performed for the entire study population, while ultra-sensitive CRP,l ipid abnormality exploration and atherogenicity index were assessed only in the overweight population.
Results
-LDH and CPK levels were significantly higher in overweight subjects com- pared with normoweight subjects. Ultra-sensitive CRP showed a positive and signi- ficant correlation with ASAT (r = 0.356*, p = 0.046) and LDH (r = 0.370*, p = 0.037). Conclusion
-The results suggest that LDH could be a promising lead in the measurement of cardiovascular risk in overweight subjects.
Downloads
Article Details
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
A- Open Access statement and license:
1-Open Access statement:
JFMO provides immediate open access to published content in support of the idea that free access to research helps support the dissemination of knowledge and ideas in the field of medical science. All articles will be published under Creative Commons licenses.
All published data is immediate free access to the work and permits any user to read, download, copy, distribute print, search, or link to the full texts of articles.
The users of any published material in the JFMO must act in accordance with the Creative Commons Licenses CC BY-NC-ND 4.0.
2-License:
All published data is distributed following the Creative Commons Licenses CC BY-NC-ND 4.0. This license is allowing others to download the works and share them with others as long as they correctly cite the manuscript, No changes are allowed to the original manuscript and the manuscript must be used only for non for profit or non-commercial purposes.
This work is licensed under a Creative Commons AttributionNonCommercial-NoDerivatives 4.0 International License.
3-Self Archiving:
Authors are permitted and encouraged to share online their articles published in JFMO (e.g., in institutional repositories or on their website), as it can lead to productive exchanges, as well as earlier and greater citation of published work.
References
Lachal J, Orri M, Sibeoni J, Moro M, Revah-Levy A. Méta-synthèse qua-
litative de l’obésité de l’enfant et de l’adolescent. Neuropsychiatrie De
L’enfance Et De L’adolescence. 1 mai 2015 ; 63(3) : 18391.
Bonnefond A, Froguel P. Génétique du diabète de type 2 et de l’obésité
: où en sommes-nous ? Que pouvons-nous en attendre ? Médecine des
Maladies Métaboliques. 1 oct 2011 ; 5(5) : 47788.
ObEpi E. Enquête épidémiologique nationale sur le surpoids et l’obési-
té. Institut National de la Santé et de la Recherche médicale, Laboratoire
Roche. 2012.
Didier A, Mailhol C. Asthme, alimentation et obésité. Revue Francaise
D Allergologie. 1 avr 2011 ;51(3):126–9.
Salaün H, Thariat J, Vignot M, Merrouche Y, Vignot S. Obésité et cancer.
Bulletin Du Cancer. 1 janv 2017 ; 104(1):3041.
GALLISSOT-PIERROT E. Pratique d’une activité physique et ses facteurs
limitants dans une population d’adultes obèses: Diminution des affects
dépressifs et possibilités d’action par le médecin généraliste. France:
Université de Lorraine; 2013
M.Atek,Y. Laid, N. Mezimech,L. Boutekjdi, H. Lebcir,L’Obésité chez
l’adulte de 35 à 70 ans en Algérie,Septembre 2010.
Nabila T. Les indicateurs de l'obésité dans une population masculine
et polymorphisme epsilon de l'APOE. Tlemcen,Algérie: Université Abou
BakrBelkaide; 2015.
Pigeyre M. Évolution des concepts physiopathologiques de l’obésité.
Presse Medicale . 1 sept 2010 ;907–12.
Faucher P, Poitou C. Physiopathologie de l’obésité. Revue Du Rhuma-
tisme Monographies. 1 févr 2016 ; 83(1) : 612.
Ottavian S. Obésité et polyarthrite rhumatoïde. Revue Du Rhumatisme
Monographies. 1 févr 2016 ; 83(1) : 29 33.
Bendriss L, Khatouri A. Les accidents vasculaires cérébraux isché-
miques. Fréquence des étiologies cardiovasculaires documentées par un
bilan cardiovasculaire approfondi. À propos de 110 cas Annales De Cardio-
logie Et D Angéologie. 2012 ; 61(4) : 252 6.
Adams JH, Abendschein DR, Jaffe AH. Biochemical markers of myocar-
dial injury. Is MB creatine kinase the choice for the 1990s ? Circulation. 1
août 1993 ; 88(2) : 750 63.
Abdelaal M, Roux CWL, Docherty NG. Morbidity and mortality asso-
ciated with obesity. Annals of TranslationalMedicine. 1 avr 2017 ; 5(7)
: 161.
Poirier P, Giles TD, Bray GA, Hong Y, Stern JS, Pi-Sunyer FX, et al. Obe-
sity and Cardiovascular Disease : Pathophysiology, Evaluation, and Effect
of Weight Loss. Circulation. 14 févr 2006 ; 113(6) : 898 918.
Swastini DA, Wiryanthini IAD, Ariastuti NLP, Muliantara A. Atheros-
clerosis Prediction with High Sensitivity C-Reactive Protein (hs-CRP) and
Related Risk Factor in Patient with Dyslipidemia. Open Access Macedonian
Journal of Medical Sciences. 14 nov 2019 ; 7(22) : 3887 90.
Saleem A, Ali A. Correlation of C-Reactive Protein and Cardiac En-
zymes with Angiographic Severity of Coronary Artery Disease in Pakistani
Patients with Acute Coronary Syndrome. 2017 ; 27(2) : 66 70.