HER2 in Cancer: Biology, Signalling and Therapeutic Perspectives
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Résumé
This comprehensive review explores the role of the HER2 receptor in cancer, from its fundamental biology to its clinical implications. HER2, a transmembrane receptor tyrosine kinase (RTK), is a key player in cellular signaling, influencing cell proliferation, survival, and migration. Its activation, primarily through dimerization, triggers major signaling pathways such as PI3K/AKT/mTOR and MAPK/ERK, which are often dysregulated in cancers. Overexpression and/or amplification of HER2 are frequently observed, notably in breast and gastric cancers, making it a crucial therapeutic target.
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Références
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Lemmon, M. A., & Schlessinger, J. (2010). Cell signaling by receptor tyrosine kinases. Cell, 141(7), 1117-1134.